Phylogenetic Patterns and the Evolutionary Process: Method by Niles Eldredge

By Niles Eldredge

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Interferon regulatory factor 1 is myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition. Cell Growth Differ 2:401-407. 27. Harada H, Kitagawa M, Tanaka N, Yamamoto H, Kharada K, Ishihara M, Taniguchi T (1993). Anti-oncogenic potentials of interferon regulatory factors -1 and -2. Science 259:971-973. 28. Willman C, Sever C, Pallavicini M, Harada H, Tanaka N, Slovak M, Yamamoto H, Harada K, List A, Taniguchi T (1993). 1, in human leukemia and preleukemic myelodysplasia.

Though speculative, it has been suggested that t(14;18) translocations may arise due to errors in the normal DNA recombination mechanisms involved in the cutting and splicing of gene segments in the IgH locus, where heavy-chain proteins are encoded in separate V, D, and J gene segments [1,28]. This speculation is based in part on the finding of sequences within or near bcl-2 on chromosome 18 that resemble the classical heptamerinonamer motifs flanking the V, D, and J gene segments, which presumably represent recognition elements for cellular recombinases.

Van den Berghe H, Vermaelen K, Mecucci C, Barbieri D, Tricot G (1985). The 5q- anomaly. Cancer Genet Cytogenet 17:189-255. 27 6. Nimer SD, Golde DW (1987). The 5q- abnormality. Blood 70:1705-1712. 7. Mecucci C, van den Berghe H (1992). Cytogenetics. HematollOncol Clin North Am 6:523541. 8. Boultwood J, Lewis S, Wainscoat JS (1994). The 5q- syndrome. Blood 84:3253-3260. 9. Nagarajan L (in press). Molecular analysis of 5q- chromosome. Leukemia Lymphoma. 10. Estey EH, Keating MJ, Dixon DO, Trujillo JM, McCredie KB, Freireich EJ (1987).

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