Genetic Influences on Response to Drug Treatment for Major by Janusz K. Rybakowski, Alessandro Serretti

By Janusz K. Rybakowski, Alessandro Serretti

Written through worldwide specialists, this booklet offers a contemporary accomplished perception into the pharmacogenetics of therapy of significant psychoses: schizophrenia, bipolar illness and melancholy. The pharmacogenomics of 3 different types of an important psychiatric medicines, antipsychotics, antidepressants and temper stabilizers, has been up to date and reviewed.

Some promising instructions and views for destiny examine in pharmacogenetics in significant psychoses are indicated. they're, between others, attached with the improvement of latest tools in molecular genetics and with linking pharmacogenetics overview with biomarkers, together with neuroimaging ones. ultimately, the makes an attempt to exploit pharmacogenetics of antipsychotic, antidepressant and mood-stabilizing medications in perform are offered. New pharmacogenetic instruments may possibly tremendously give a contribution to introducing customized medication into psychiatric medical perform.

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3 Oxidative Stress Genes Oxidative stress and the resultant reactive oxygen species (ROS) are suggested to cause neuronal degeneration and contribute to TD. Neuronal cells have been shown to be highly sensitive and prone to oxidative damage [47]. Thus, conferring 2 Pharmacogenetics of Serious Antipsychotic Side Effects 25 oxidative stress and antioxidant pathway-related genes have been described as promising candidates for genetic studies of TD. One such candidate gene is the mitochondrial enzyme manganese superoxide dismutase (MnSOD).

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Laughlin C, Mallya KS, McCracken JT et al (2015) Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes. Pharmacogenomics 16(1):5–22 2 Pharmacogenetics of Serious Antipsychotic Side Effects 37 69. Renou J, De Luca V, Zai CC, Bulgin N, Remington G, Meltzer HY, Lieberman JA, Le Foll B, Kennedy JL (2007) Multiple variants of the DRD3, but not BDNF gene, influence age-atonset of schizophrenia. Mol Psychiatry 12(12):1058–1060 70. Risselada AJ, Vehof J, Bruggeman R, Wilffert B, Cohen D, Al Hadithy AF, Arends J, Mulder H (2012) Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study.

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