Current topics in cellular regulation by Bernard L. Horecker, Earl R. Stadtman

By Bernard L. Horecker, Earl R. Stadtman

Present subject matters in mobile law, quantity 20 evaluates the fundamental mechanisms concerned about the legislation of numerous mobile activities.

This publication discusses the function of glutamine within the circulate of nitrogen, legislation of glycogen synthase job by means of covalent phosphorylation, and physiological position of PFK phosphorylation. The in vivo modulation of HMG-CoA reductase job, hypotheses at the position of eIF-2 phosphorylation, and ADP-ribosyltransferase from turkey erythrocytes also are elaborated. this article likewise covers the non-enzymic results of vanadate and phosphorylation of liver and muscle PFK.

This quantity is an effective resource for biologists and researchers drawn to advances within the normal region of mobile law.

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Current topics in cellular regulation

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117). CoA decreases, some of the enzyme molecules no longer have acetylCoA bound and therefore rapidly undergo dilution inactivation. This loss of activity is compounded since any acetyl-CoA-free enzyme molecules which have not undergone dilution inactivation cannot catalyze the reaction at a maximum rate since they are no longer saturated with HCO a - and pyruvate. The combination of these two factors leads to the observed sigmoidal velocity response at low acetyl-CoA concentrations. In order to eliminate these difficulties, Easterbrook-Smith et ai.

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