Chromosome Aberrations (Reprint of Cytogenetic and Genome by G. Obe (Editor), A. T. Natarajan (Editor)

By G. Obe (Editor), A. T. Natarajan (Editor)

Show description

Read or Download Chromosome Aberrations (Reprint of Cytogenetic and Genome Research 2004) PDF

Best genetics books

Phylogenetics

'Phylogenetics' is the reconstruction and research of phylogenetic (evolutionary) bushes and networks in line with inherited features. it's a flourishing sector of intereaction among arithmetic, facts, laptop technological know-how and biology. the most function of phylogenetic strategies lies in evolutionary biology, the place it truly is used to deduce historic relationships among species.

Human Genetics and Society

Super student-friendly and entirely appropriate, HUMAN GENETICS AND SOCIETY, First version, makes the fundamental ideas and procedures of genetics genuine by means of addressing matters that relate on to your lifestyles, permitting you to make expert judgements. absolutely integrating technological know-how and social matters, the textual content offers the fundamentals of human genetics within the context of the problems that outcome from the flood of goods, providers, and methods built from genetic wisdom.

Global clinical trials : effective implementation and management

This e-book will discover the nice possibilities and demanding situations which exist in undertaking medical trials in constructing international locations. by means of exploring some of the laws particular to the main avid gamers and supplying perception into the logistical demanding situations together with language obstacles, this ebook offers a operating instrument for medical researchers and directors to navigate the intricacies of scientific trials in constructing international locations.

Extra resources for Chromosome Aberrations (Reprint of Cytogenetic and Genome Research 2004)

Example text

The frequencies in the Ku70-deficient cells were not significantly different from those of the isogenic parental DT40 cells, indicating that the NHEJ pathway was not a significant determinant of the spontaneous and MMCinduced SCEs and CAs. The frequencies of the spontaneous CAs were significantly elevated in all cell lines deficient in Cytogenet Genome Res 104:28–34 (2004) 29 Fig. 1. The frequencies of CAs and SCEs in untreated and MMC-treated DT40 cells with different genetic background. (A) CAs.

Relationship between MMC-induced SCEs and CAs. The netinduced frequency of CAs is plotted against the net-induced frequency of SCEs. The dotted line shows a 1:1 correlation or equivalent reduction. the HR genes, namely, Rad54–/–, Rad51B–/–, Rad51C–/–, Rad51D–/–, Xrcc2–/– and Xrcc3–/– cells. Thus, impaired HR constitutes the genetic basis of the chromosomal instability. However, the effects of HR deficiency on MMC-induced CAs, and spontaneous and MMC-induced SCEs were different among the mutants.

Hum Mol Genet 12:2503–2510 (2003). Ivanov EL, Korolev VG, Fabre F: XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination. Genetics 132:651–664 (1992). Joenje H, Patel KJ: The emerging genetic and molecular basis of Fanconi anaemia. Nature Rev Genet 2:446–457 (2001). Kanaar R, Hoeijmakers JH, Van Gent DC: Molecular mechanisms of DNA double strand break repair. Trends Cell Biol 8:483–489 (1998). Kano Y, Fujiwara Y: Role of DNA interstrand crosslinking and its repair in the induction of sisterchromatid exchange and a higher induction in Fanconi’s anemia cells.

Download PDF sample

Rated 4.42 of 5 – based on 46 votes