Bipolar Depression: Molecular Neurobiology, Clinical by Carlos A. Zarate Jr., Husseini K. Manji

By Carlos A. Zarate Jr., Husseini K. Manji

This e-book brings jointly psychological well-being pros and researchers to provide the main updated details at the analysis, remedy, and learn surrounding bipolar melancholy. Its person chapters supply beneficial diagnostic details, permitting clinicians to tell apart among a few of the temper issues. extra, they: assessment the path, consequence, and genetics of this hugely heritable situation; provide an intensive evaluate of the neurobiology of the ailment, together with what's recognized from neuroimaging paintings; delineate the remedy of bipolar melancholy in distinctive populations equivalent to teenagers and pregnant girls; tackle suicide, targeting the necessity for review in the course of either acute and upkeep remedy with interventions applicable to a patient’s signs and heritage; and canopy acute and long term therapy recommendations for bipolar melancholy, together with either conventional and novel therapeutics for the ailment, in addition to non-pharmacological treatments.

This moment version displays major advances, together with a stronger realizing of the altered neurobiology of sufferers struggling with bipolar melancholy, new details on pathophysiology and genetic findings drawn from assorted experiences, and a dialogue of the numerous strides made in the direction of enhanced remedy with already on hand and novel agents.

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Extra info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy

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It is possible that all these stages require specific therapeutic interventions, and the impact of comorbidity, specific treatment, personality, adherence, and response to therapy could differ in each stage. In general, a greater number of episodes imply a progression to a later stage with poorer treatment response and prognosis. The 38 R. Escalona and M. Tohen persistence of neurocognitive impairment is associated with poorer psychosocial functioning at any stage. Peripheral biomarkers of inflammation are more likely present at the end stage of BD, consistent with the hypothesis of a neuroprogression of the illness (Kauer-Sant’Anna et al.

8 R. Escalona and M. Tohen Comorbidity BD has frequent comorbidities that worsen prognosis, especially in association with substance-use disorders (Tohen 1999; Tohen et al. 1998). The relative age at onset of alcohol use and BD is associated with differences in the course of both conditions. A first hospitalization for mania is associated with a period of recovery from comorbid alcohol abuse (Strakowski et al. 1992, 2005). Those patients with alcohol-use problems prior to BD are usually older, more likely to recover, and more likely to recover quickly than those whose alcohol problems occur after their diagnosis of BD.

However, early morning wakening is a common feature in any anxiety or depressive condition marked with physiological arousal, so that early morning wakening may be quite common in those with mixed anxiety/ depression and with grief states as well as in those with other expressions of non-melancholic depression. 4 Psychotic Features The nature of psychotic depression remains somewhat unclear, with the two commonest models viewing it either as a more severe form of melancholia or as melancholia with superimposed (and categorical) features of delusions and/or hallucinations.

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