Biopsy Interpretation of the Central Nervous System by Matthew J. Schniederjan MD, Daniel J. Brat MD PhD

By Matthew J. Schniederjan MD, Daniel J. Brat MD PhD

It is a functional advisor and concise reference that may be a spouse textual content for the final surgical pathologist, trainees in pathology and neuropathology, and clinicians who deal with sufferers with neurological ailments that require surgical sampling.

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The histology of cerebral Whipple’s disease is that of a macrophagerich lesion with variable amounts of lymphocytes and plasma cells. The macrophages contain irregular, polymorphous, sometimes sickle-shaped, fragments of PAS-positive, diastase-resistant material in otherwise foamy INFLAMMATORY AND INFECTIOUS LESIONS ——— 23 cytoplasm. A perivascular distribution of the macrophages is often apparent. Gram and GMS stains also label this organism. TOXOPLASMOSIS Infection with this protozoan parasite is widespread among mammals.

The tumor’s epicenter usually lies within the white matter. Areas of brain permeated by neoplastic cells are often expanded, causing subtle mass effects on surrounding structures. Spread from one hemisphere to the other along the corpus callosum or a commissure is typical for infiltrating astrocytomas. 39 40 ——— BIOPSY INTERPRETATION OF THE CENTRAL NERVOUS SYSTEM FIGURE 3-1 T2-weighted magnetic resonance imaging (MRI) shows increased signal in areas with higher water content (edema) and demonstrate the extension of grade II astrocytomas through white matter, here reaching to the contralateral hemisphere.

2010;29(3):156–62. 12. Uruha, A, R Koide, and M Taniguchi, Unusual presentation of sarcoidosis: solitary intracranial mass lesion mimicking a glioma [published online ahead of print August 7, 2009]. J Neuroimaging. x 13. Veres, L, JP Utz, and OW Houser, Sarcoidosis presenting as a central nervous system mass lesion. Chest. 1997;111(2):518–21. 14. Cunningham, JA, Characteristics of stellate inclusions in giant cells and the associated tissue reactions. Am J Pathol. 1951;27(5):761–81. 15. , Necrotizing neurosarcoid: three cases with varying presentations.

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