Biomarkers of brain injury and neurological disorders by Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy

By Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy

''This e-book explores the new advances within the suggestions and systems utilized in biomarker study that experience revolutionized the way in which we research, diagnose, and deal with mind damage stipulations. The individuals describe varied biomarker reviews referring to mind harm and different neurological issues and research the several versions and applied sciences used to spot those organic markers. The booklet includes Read more...

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Meerhoff and A. Twijnstra. 2001. S-100B and neuronspecific enolase in serum of mild traumatic brain injury patients A comparison with healthy controls. Acta Neurol Scand. 103: 175–179. , I. Lyons, C. Koutzoukis, I. Ali and G. McCarthy. 1999. Rate of psychiatric illness 1 year after traumatic brain injury. Am J Psychiat. 156: 374–378. , D. Amin, S. Pernagallo, G. Lazzarino, B. Tavazzi, R. Vagnozzi, A. Pringle and A. Belli. 2010. Transcriptomics of traumatic brain injury: gene expression and molecular pathways of different grades of insult in a rat organotypic hippocampal culture model.

Pediatr Neurosci. 45: 262–270. , J. Ptacek and M. Snyder. 2007. Protein microarray technology. Mech Ageing Dev. 128: 161–167. , M. Wetterhall, P. Enblad, L. Hillered and J. Bergquist. 2009. Temporally resolved differential proteomic analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidates. J Neurosci Meth. 177: 469–478. S. Hutchison, R. B. Stanimirovic. 2007. Biomarkers and diagnosis; protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS.

2004)). 3. Overview of Proteomics-Based Biomarker Discovery: In brief, samples are separated by gel-based or gel-free techniques, digested and then processed into MS that allows for identification of differentially expressed proteins with the help of online databases. The obtained list of differentially expressed proteins provide an insight into candidate biomarkers that can be further validated by traditional molecular biology tools like Western blot. Further use of systems biology protein interaction analysis tools allows for analysis and visualization of resulting data in terms of interacting proteins and protein networks.

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