Benign Tumors of the Liver by Luca Aldrighetti, Francesco Cetta, Gianfranco Ferla

By Luca Aldrighetti, Francesco Cetta, Gianfranco Ferla

Diagnosis of benign liver tumors is experiencing exponential development, normally because of the diffusion of extra actual imaging ideas. This monograph examines the epidemiology, histopathology and genetics of those tumors and gives a scientific evaluate in their evolution and differential analysis. Care is taken to rfile surgical symptoms thoroughly, on the way to helping within the avoidance of lifeless interventions. Open, laparoscopic and robot surgical ideas are defined and illustrated, emphasizing the optimization of intra- and postoperative administration in an effort to keep away from strength issues and degeneration. In those chapters, consciousness is attracted to the ways that the surgical administration of benign liver tumors differs from that of malignant tumors. The publication concludes by way of studying the function of interventional radiology in sufferers with benign liver tumors.

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4–25 % of affected siblings develop HA. The estimated risk of malignant transformation of hepatic adenomas related with type I GSD is as high as 10 %, whereas the risk for malignant transformation is much lower in patients with type II GSD. In fact, only six patients have been reported up to now in the literature. All these findings suggest that increased glycogen storage in the liver seems to induce hepatic tumorigenesis, likely altering glucose metabolism and glycogen synthesis. ” Other hereditary diseases, acting as risk factors associated, namely, with hepatic adenomas [5–8] include: (1) galactosemia, (2) hepatic iron overload related to beta thalassemia, and (3) maturity-onset diabetes of the young type 3 (MODY3) [4].

J Natl Cancer Inst 97:813–822 3 Genetic Syndromes and Benign Liver Tumors 33 15. Giardiello F, Petersen G, Bresinger J et al (1996) Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 39:867–869 16. Hirschman BA, Pollock BH, Tomlison GE (2005) The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds. J Pediatr 147:263–266 17. Cetta F, Dhamo A, Civitelli S et al (2008) Extraintestinal manifestations of familial adenomatous polyposis.

Bioulac-Sage P, Blanc JF, Rebouissou S et al (2007) Genotype phenotype classification of hepatocellular adenoma. World J Gastroenterol 13:2649–2654 6. Zucman-Rossi J, Jeannot E, Nhieu JTV et al (2006) Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 43:515–524 7. Bioulac-Sage P, Laumonier H, Couchy G et al (2009) Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology 50:481–489 8. Bioulac-Sage P, Rebouissou S, Thomas C et al (2007) Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry.

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