Anaerobic Infections: Diagnosis and Management by Itzhak Brook

By Itzhak Brook

With new infectious brokers, antibiotics, and situations of antimicrobial resistance always at the horizon, this box is an ever starting to be self-discipline that calls for consistent vigilance. This e-book responds to burgeoning progress within the box and gives a complete and professional armamentarium of instructions for the remedy and prognosis of the total breadth of grownup and pediatric anaerobic infections.

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Coli. The most common anaerobic organisms are Prevotella bivia, Prevotella disiens, B. fragilis group, P. acnes, Peptostreptococci, pigmented prevotella and porphyromonas, clostridia, and lactobacilli (36). The newborn is colonized initially on the skin and mucosa of the nasopharynx, oropharynx, conjunctivae, umbilical cord, and the external genitalia. In most infants, the organisms colonize these sites without causing any inflammatory changes. The colonization of the gastrointestinal tract by bacteria begins immediately after delivery.

The oropharynx is seldom colonized by Enterobacteriaceae. In contrast, hospitalized patients are often colonized with these organisms. This may be due to selection following the administration of antimicrobials (11) and can contribute to the development of anaerobic gram negative bacilli (AGNB) pneumonia. Oropharyngeal selective decontamination using topical polymyxin B, neomycin, and vancomycin is effective in reducing colonization and pneumonia with S. aureus and AGNB, without suppression of anaerobes organisms (12).

Sbordone L, Bortolaia C. Oral microbial biofilms and plaque-related diseases: microbial communities and their role in the shift from oral health to disease. Clin Oral Investig 2003; 7:181–8. 10. Lovegrove JM. Dental plaque revisited: bacteria associated with periodontal disease. J NZ Soc Periodontol 2004; 87:7–21. 11. Hiar I, Tande D, Gentric A, Garre M. Oropharyngeal colonization by gram-negative bacteria in elderly hospitalized patients: incidence and risk factors. Rev Med Interne 2002; 23:4–8.

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