Am I My Genes?: Confronting Fate and Family Secrets in the by Robert Klitzman

By Robert Klitzman

Within the fifty years seeing that DNA was once chanced on, we've seen amazing advances. for instance, genetic checking out has speedily more suitable the analysis and therapy of illnesses corresponding to Huntington's, cystic fibrosis, breast melanoma, and Alzheimer's. yet with this new wisdom comes tricky judgements for numerous humans, who strive against with worry approximately no matter if to get proven, and if this is the case, what to do with the consequences. Am I My Genes? indicates how genuine participants have faced those concerns of their day-by-day lives.

Robert L. Klitzman interviewed sixty four those that confronted Huntington's ailment, breast and ovarian melanoma, or Alpha-1 antitrypsin deficiency. The booklet describes--often within the person's personal words--how every one has wrestled with the giant implications that genetics has for his or her lives and their households. Klitzman exhibits how those women and men fight to make experience in their drawback and its explanations. They confront a chain of quandaries--whether to be demonstrated; even if to reveal their genetic hazards to folks, siblings, spouses, offspring, buddies, medical professionals, insurers, employers, and faculties; tips on how to view and comprehend themselves and their genetics; what remedies, if any, to pursue; even if to have young children, undertake, display embryos, or abort; and no matter if to take part in genetic groups. within the face of those uncertainties, they've got attempted to appreciate those exams and chances, keep away from fatalism, nervousness, depression, and discrimination, and locate desire, that means, and a feeling of wholeness. compelled to wander via a desert of moving sands, they chart paths that many others may perhaps finally stick to.

Klitzman captures right here the voices of pioneers, the various first to come across the non-public dilemmas brought by means of sleek genetics. Am I My Genes? is a useful account in their event, person who becomes the entire extra universal within the coming years.

"An impressive exploration...probing the numerous roles and implications of genetics in our lives today.... full of excellent insights, this riveting ebook is key interpreting for us all." -- Paula Zahn

"Klitzman lucidly discusses the ethical and mental complexities that are available in the wake of genetic testing.... a big ebook for somebody who has the genes for pathology, that's we all, and that i suggest it highly." -- Kay Redfield Jamison, writer of An Unquiet brain

"An illuminating voyage in the course of the scientific, familial and existential quandaries confronted via these people at genetic risk." -- Thomas H. Murray, President and CEO, The Hastings heart Show

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Extra info for Am I My Genes?: Confronting Fate and Family Secrets in the Age of Genetic Testing

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3 Oxidative Stress Genes Oxidative stress and the resultant reactive oxygen species (ROS) are suggested to cause neuronal degeneration and contribute to TD. Neuronal cells have been shown to be highly sensitive and prone to oxidative damage [47]. Thus, conferring 2 Pharmacogenetics of Serious Antipsychotic Side Effects 25 oxidative stress and antioxidant pathway-related genes have been described as promising candidates for genetic studies of TD. One such candidate gene is the mitochondrial enzyme manganese superoxide dismutase (MnSOD).

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Laughlin C, Mallya KS, McCracken JT et al (2015) Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes. Pharmacogenomics 16(1):5–22 2 Pharmacogenetics of Serious Antipsychotic Side Effects 37 69. Renou J, De Luca V, Zai CC, Bulgin N, Remington G, Meltzer HY, Lieberman JA, Le Foll B, Kennedy JL (2007) Multiple variants of the DRD3, but not BDNF gene, influence age-atonset of schizophrenia. Mol Psychiatry 12(12):1058–1060 70. Risselada AJ, Vehof J, Bruggeman R, Wilffert B, Cohen D, Al Hadithy AF, Arends J, Mulder H (2012) Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study.

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